Embryo Glue Pros and Cons

Embryo glue, sometimes referred to as an embryo transfer medium, is a specifically formulated fluid intended to resemble the uterus' organic environment. In the vital phase of implantation, it offers an adhesive property that aids the embryo in adhering to the uterine wall. The glue contains hyaluronan, a natural component in the female reproductive tract, which improves embryo-uterine lining interaction and attachment.

Embryo Glue Pros and Cons


The ability to boost the implantation rate is one of the key benefits of employing embryo glue. According to studies, using embryo glue during IVF treatments may increase the likelihood of becoming pregnant. The embryo may stay in the desired position for implantation due to the glue's adhesive characteristics, which may lower the chance of embryo displacement during transfer. The glue may additionally improve the likelihood of successful implantation by facilitating an enhanced embryo-maternal connection.


Although embryo glue has the potential to increase implantation rates, scientific data supporting its efficacy is limited. Some studies document successful results, while others reveal no appreciable variation in conception rates from conventional transfer techniques. Embryo glue candidates must be aware of this limitation.

Like any medical procedure, glue components may cause allergic reactions or other side effects. Additionally, using embryo glue increases the cost of IVF procedures; this fact must be considered while designing a treatment plan.

Success Rate

Embryo glue may increase the likelihood of success by 7% to 9%. However, the efficacy rate of embryo glue can vary depending on patient characteristics and clinical expertise. Although some studies show that using embryo glue increases conception rates significantly, other research shows contradicting results. The efficacy of embryo glue may depend on the patient's age, health, and infertility history.

Side effects 

The side effects of embryo glue have been observed to be minor and similar to those associated with regular IVF techniques. Although serious adverse effects are extremely rare, some patients may feel little discomfort or irritability. 


The price of embryo glue varies based on the facility and area. It costs approximately Rs. 10,000/- to Rs. 20,000/- in India. The price range in the UK is between £200 and £400.


Even though embryo glue has demonstrated potential for improving implantation rates, it is not the sole choice. Different methods or processes, such as the use of a particular culture medium or embryo selection techniques, may be used by fertility clinics to improve embryo transfer. These consist of:

Natural Alternatives:

Uterine environment optimization

Endometrial scratching

Synthetic Substitutes:

Hyaluronic acid-based products

Synthetic adhesion molecules

Calcium-rich culture media


In a nutshell, embryo glue is a specific product designed to increase the likelihood of a fruitful embryo implantation during IVF procedures. Although it has the potential to increase implantation rates, there is currently insufficient scientific proof of its efficacy. Patients thinking about using embryo glue should speak with their fertility doctors, examine the benefits and drawbacks, and then decide depending on their individual situation and medical history.


Is embryo glue safe to use during IVF?

While embryo glue is generally regarded as safe, people with allergies or other sensitivities should speak with their fertility doctors.

Does embryo glue guarantee a successful pregnancy?

No, embryo glue does not ensure pregnancy. It can, however, raise the likelihood of successful implantation.

How does embryo glue differ from traditional transfer methods?

The embryo's adhesion to the uterine wall during implantation is enhanced by the adhesive properties of embryo glue.

Can embryo glue be used in all IVF cases?

Embryo glue may be indicated in certain scenarios, however each patient's situation is unique and requires a specialized review.

What are the alternatives if I decide not to use embryo glue?

Other techniques or procedures for optimizing embryo transfer may be available at fertility clinics, and patients should discuss these options with their healthcare provider.

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